4/15/2023 0 Comments Brcapro software downloadThe models were assessed using Brier scores, attributes diagrams and receiver operating characteristic curves. Observed BRCA1 and BRCA2 mutation status was compared with predicted carrier probabilities under the BOADICEA and BRCAPRO models. MethodsĪ total of 195 families with multiple affected individuals with breast or ovarian cancer were recruited through the INHERIT (INterdisciplinary HEalth Research International Team on BReast CAncer susceptibility) BRCAs research program. We also used this data set to estimate the age-specific risks for breast and ovarian cancer in BRCA1 and BRCA2 mutation carriers. We used data from French-Canadian families to evaluate the mutation predictions given by the BRCAPRO and BOADICEA models. Several genetic risk models for breast and ovarian cancer have been developed, but their applicability to specific populations has not been evaluated.
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